This book explores the life-worlds and clinical experiences of people diagnosed with a severe psychiatric disorder inside the Lutindi Mental Hospital, in the Tanzanian Usambara Mountains. Here, different meaning systems of mental illnesses shape treatment trajectories and illness outcomes. What led to these different understandings and what consequences do they have for the treatment of patients? To answer this question, I will tell the story of two definitions of the concept of mind: as the brain itself, and as the content of human thoughts. I will show that global and local representations of the mind collide inside the hospital, and how this collision affects the clinical experience of people diagnosed with a severe psychiatric illness. This emerging tension was not just the consequence of a biomedical hegemonic process, but it was also embedded in the historical trajectory and the moral fabric surrounding the hospital, as well as in the development of psychiatric care in the country.