This book arises from the need inside the European process industry to innovate existing manufacturing processes towards sustainability. Next to this sector, startups and scale ups of novel manufacturing routes want to do sustainability first time right. Methodically, the book describes and analyzes technological, economical, psychological and organizational factors that prevent innovation in companies. Subsequently, a unique innovation method is presented. It is inside-out, meaning innovation promoting and inhibiting factors are identified and companies are coached to innovate their own process. To inspire and motivate, a comprehensive set of state-of-art technologies is interfaced with company manufacturing processes. The uniqueness of the method lies in the fact, it is structured yet leaves room for creativity. It builds on fundamental driving forces encountered in physics and chemistry. It starts in reality, reaches technological abstractness and then comes back with a realistic innovation. Finally, it is the company itself that innovates. This book can support companies dealing with innovating their existing manufacturing processes and for start/scale ups that want to be sustainable right from the start.