Inhaltsangabe1 The organization of the sphingosine-1-phosphate signaling systemHugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera and Edward Roberts# 2 Structural biology of the S1P1 receptorMichael A. Hanson and Robert Peach 3 Chemical and genetic tools to explore S1P biologyStuart M. Cahalan 4 S1P control of endothelial integrityYuquan Xiong and Timothy Hla 5 Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleenTal I. Arnon and Jason G. Cyster  6 Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist moleculeMichael B.A. Oldstone and Hugh Rosen 7 Sphingosine-1-phosphate and central nervous systemRoland Martin and Mireia Sospedra 8 RORs in autoimmune diseaseM. Chang, H. Rosen and Patrick Griffin