. 25 Chapter 3 Does the Second Law of Thermodynamics Refute the Neo-Darwinian Synthesis? BRUCE H. WEBER and DAVID 1. DEPEW. 50 CONTENTS Partll Natural Selection and Developmental Systems: Redrawing the Boundaries Between Genetic and Non-Genetic Factors of Evolution Chapter 4 Evolutionary and Developmental Formation: Politics of the Boundary SUSAN OyAMA.