InhaltsangabeBasic Studies



I. Molecular Mechanisms of Estrogen Receptor Function



Structure and Function of the Estrogen Receptor

Stefan Nilsson and Jan-Åke Gustafsson



LigandInduced Conformational Changes in Estrogen Receptorsa and b

Elizabeth A. Allegretto



Expression and Function of Estrogen Receptors-a and -b

Jonathan Lindzey



SERM Modulation of Gene Expression: Role of Coactivators and Corepressors

Paul Webb



Crosstalk Between Estrogen Receptors and Growth Factor Signaling

Douglas Yee and Carol A. Lange



II. TissueSpecific Effects of Estrogens and SERMs



Direct Estrogen Effects on the Cardiovascular System

Munish K. Goyal and Suzanne Oparil



Estrogens and the Brain: Implications for the Treatment of Postmenopausal Women

Bruce S. McEwen, Phyllis M. Wise, and Stanley Birge



III. Preclinical Studies



Insights into the Molecular Mechanism of SERMs Through New Laboratory Models

Csaba Gajdos, James Zapf, and V. Craig Jordan



Third and FourthGeneration SERMs, Fernand Labrie

Claude Labrie, Alain Bélanger, and Jacques Simard



Clinical Studies



IV. Organ Specific Effects of Estrogens and SERMs



SERMs' Effect on the Neuroendocrine System and the Reproductive Organs

Nanette F. Santoro and Peter Kovacs



Epidemiology of Cardiovascular Disease in Women: Role of Estrogens

Jacques E. Rossouw



SERMs Effects on Cardiovascular Risk Factors and Disease

Richard R. Love



Estrogen and the Skeleton

Michael Kleerekoper and Ashish Verma



Effects of SERMs on Bone in Clinical Studies

Aurelie Fontana and Pierre D. Delmas



Estrogens and SERMs: Clinical Aspects of Cognition with Aging and Neurodegenerative Disorders

Alan J. Lerner



V. SERMs and Endocrine Dependent Tumors



SERMs and Breast CancerPrevention

Jenny Chang and C. Kent Osborne



SERMs in Postmenopausal Women's Health

Jan L. Shifren and Leo Plouffe, Jr.



VI. Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy



Menopause Therapy: An Individualized Approach

Nananda F. Col, Michele G. Cyr, and Anne W. Moulton



Alternatives to Estrogen for Treatment of Menopause

Richard J. Santen and JoAnn V. Pinkerton



Phytoestrogens in the Context of SERMs

Susan R. Davis