This book dealing with connecting the science of microfluidic rheology and the bio-polymer composite materials, to create bio-polymer microspheres made from natural sources. The microspheres morphology produced using the microfluidic device varied as flow rate decreased. This create many shapes of microspheres that acted individually for each flow rate. The degradation of these microspheres had been affected by the shape changing of each microsphere. The microspheres producing process simulated to define the causes by which the microspheres behaved individually for each case as decomposed in PBS.