Objective of the present study is to prolong the delivery of the active drug in the oral cavity using a suitable carrier such as in situ gels which can effectively deliver the drug for an extended duration of time hence not only reduce the systemic side effects but also improve the therapeutic efficacy, patient compliance. Local drug delivery systems are better suitable for antifungal drugs particularly for oral thrush. Over the past two decades, extensive research has been performed in the design of polymeric drug delivery systems. Among them, new series of thermosensitive, ion induced and pH sensitive in situ gel systems are potential carriers of antifungal drugs for oral thrush These systems are made of biodegradable polymers, which can be injected via a syringe into the infected area where the solution translate in to gel depot. Smart polymeric systems represent promising means of delivering the drugs; these polymers undergo sol-gel transition in accordance with the biological stimuli like pH change, temperature modulation and ion exchange. The purpose of the present investigation is to develop the in situ gel formulations containing the antifungal agents such as Clotrimazol