Having a child with a chronic disease may cause anxiety and depression and impair the sleep quality in the parents. Taking care of the sick child by the parents-who are usually the main care takers- can be associated with high loads of stress and result in behavioral problems like anxiety, depression and disturbance in sleep quality. This experience is commonly perceived as a chronic stressor, and caregivers often experience negative psychological, behavioral, & physiological effects on their daily lives and health. The caregiver reported extremely high levels of psychological distress, including anxiety, depression. Present study showed a significant association between depression-anxiety and sleep quality in parents with asthmatic children. Therefore, children with and their parents need to be assessed for the requirement of support regarding depression- anxiety status and sleep quality. The importance of identifying caregivers at risk of negative health outcomes and intervening to attenuate the stress associated with the caregiving experience. This book is based on the original research presented at EAN 2015 Conference, July 22-23, 2015 in Berlin, Germany.