Quercetin nanoemulgel are established as one of the most promising carriers for topical delivery system. Therefore, the aim of the present study was to develop a poloxamer 188 based nanoemulgel of quercetin with a view to improve its high capacity to hold water, without dissolving into the aqueous medium. Nanoemulgel of quercetin were developed by probe sonicator and evaluated for particle size, refractive index, gel strength, spreadability, mucoadhesive force and viscosity.