The Nobel Prize in Chemistry; Awarded to 178 Nobel Laureates since 1901 awarded for the Greatest Benefit to Mankind which focuses on this topic along with the Nobel Laureates who achieved the accolade of Nobel Prize in Chemistry (1901-2017) by playing games with chemical molecules. Playground means the domain where the chemicals react with each other which may be in-house (domestic sector) or out-house (overall sector). Functional group means the active part in the molecule which takes part in extracurricular activities to focus on the chemical reactivity. The Nobel Prize in Chemistry; Awarded to 178 Nobel Laureates since 1901. Dhrubo Jyoti Sen and Shruti Rai; Chemistry is a playground of functional groups: Lambert Academic Publishing GmbH & Co. KG, Germany: 1-373, 2016. (ISBN: 978-3-659-90892-7) This book chapter focuses on the application of chemistry into the various sectors for the greatest benefit to mankind. Chemistry is no doubt a vast subject which focuses on various molecules either inorganic or organic. These molecules are classified into various domains with their outcome for the human benefits.